Article

Steroid sulfatase deficiency increases the frequency and persistence of ventricular arrhythmias in mice

2026-07-25

Abstract excerpt

<h4>Background</h4> Emerging evidence in humans has linked Xp22.31 genetic deletions to an increased risk of stress-induced arrhythmias, and association analysis across Xp22.31 has shown enrichment for atrial fibrillation genetic risk variants around STS (steroid sulfatase). <h4>Methods</h4> We compared heart rhythm in homozygous ‘STS-knockout’ (STS-KO) adult mice (n=19) to wildtype (WT) mice (n=11) under base...

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Literature Corpus work: 17e32486-cb86-5ab0-a79f-0da66a009746
DOI: 10.64898/2026.07.22.739997

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