Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tbx5-dependent pathway regulating diastolic function in congenital heart disease

31 Mar 2008

Abstract excerpt

At the end of every heartbeat, cardiac myocytes must relax to allow filling of the heart. Impaired relaxation is a significant factor in heart failure, but all pathways regulating the cardiac relaxation apparatus are not known. Haploinsufficiency of the T-box transcription factor Tbx5 in mouse and man causes congenital heart defects (CHDs) as part of Holt-Oram syndrome (HOS). Here, we show that haploinsufficiency...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy and Myosin Studies
Share to Cardiovascular Function and Risk Factors
Share to Congenital heart defects research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18378906
DOI: 10.1073/pnas.0801779105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tbx5-dependent pathway regulating diastolic function in congenital heart diseasePMID 18378906Read ↗

The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction systemSemantic proximity Read ↗

Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm.Semantic proximity Read ↗

A Murine Model of Holt-Oram Syndrome Defines Roles of the T-Box Transcription Factor Tbx5 in Cardiogenesis and DiseaseSemantic proximity Read ↗

TBX5 drives Scn5a expression to regulate cardiac conduction system functionSemantic proximity Read ↗

Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis.Semantic proximity Read ↗

TBX5 dosage governs ventricular cardiomyocyte maturation, specialization and dedifferentiation <i>in vivo</i>Semantic proximity Read ↗

TBX5 mutations in non-Holt-Oram syndrome (HOS) malformed hearts.Semantic proximity Read ↗

Functional analysis of novel TBX5 T-box mutations associated with Holt-Oram syndrome.Semantic proximity Read ↗

Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease.Semantic proximity Read ↗

Regulatory variation in a TBX5 enhancer leads to isolated congenital heart diseaseSemantic proximity Read ↗

Dose-dependent sensitivity of human 3D chromatin to a heart disease-linked transcription factorSemantic proximity Read ↗

Role of Dyadic Proteins in Proper Heart Function and DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.