Article

ATF4 alleviates doxorubicin-induced cardiomyopathy through H <sub>2</sub> S-mediated antioxidation

2025-09-11

Abstract excerpt

<h4>Background</h4> Doxorubicin (DOX) remains a cornerstone in the treatment of various cancers. However, its clinical utilization is significantly hampered by dose-dependent cardiotoxicity. The generation of reactive oxygen species (ROS) constitutes the central component of the pathogenesis of DOX-induced cardiotoxicity. Activating transcription factor 4 (ATF4) has been demonstrated to exert a cardioprotective e...

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Literature Corpus work: 657e2a95-e4e7-57ce-89e8-d814fdb69414
DOI: 10.1101/2025.09.03.674119

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