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Article

Novel mutation in the α-myosin heavy chain gene is associated with sick sinus syndrome.

Circulation. Arrhythmia and electrophysiology - 1 Apr 2015

Ishikawa Taisuke, Jou Chuanchau J, Nogami Akihiko, Kowase Shinya, Arrington Cammon B, Barnett Spencer M, Harrell Daniel T, Arimura Takuro, Tsuji Yukiomi, Kimura Akinori, Makita Naomasa

Abstract excerpt

BACKGROUND: Recent genome-wide association studies have demonstrated an association between MYH6, the gene encoding α-myosin heavy chain (α-MHC), and sinus node function in the general population. Moreover, a rare MYH6 variant, R721W, predisposing susceptibility to sick sinus syndrome has been identified. However, the existence of disease-causing MYH6 mutations for familial sick sinus syndrome and their...

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Source

Identifiers

PMID: 25717017
DOI: 10.1161/CIRCEP.114.002534

Genes

MYH6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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