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Article

A causal role for TRESK loss of function in migraine mechanisms

12 Nov 2019

Abstract excerpt

The two-pore potassium channel, TRESK has been implicated in nociception and pain disorders. We have for the first time investigated TRESK function in human nociceptive neurons using induced pluripotent stem cell-based models. Nociceptors from migraine patients with the F139WfsX2 mutation show loss of functional TRESK at the membrane, with a corresponding significant increase in neuronal excitability....

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PMID: 31742594
DOI: 10.1093/brain/awz342

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