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Article

Functional analysis of a migraine-associated TRESK K+ channel mutation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 31 Jul 2013

Liu Ping, Xiao Zheman, Ren Fei, Guo Zhaohua, Chen Ziwei, Zhao Hucheng, Cao Yu-Qing

Abstract excerpt

Recent genetic and functional studies suggest that migraine may result from abnormal activities of ion channels and transporters. A frameshift mutation in the human TWIK-related spinal cord K(+) (TRESK) channel has been identified in migraine with aura patients in a large pedigree. In Xenopus ooc...

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Identifiers

PMID: 23904616
DOI: 10.1523/JNEUROSCI.1237-13.2013
PMCID: PMC3728689

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23904616-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Functional analysis of a migraine-associated TRESK K+ channel mutation.PMID 23904616Read ↗

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KCNK18 c.1107del frameshift in peripheral neuropathy links TRESK dysfunction to neuropathic painSemantic proximity Read ↗

A causal role for TRESK loss of function in migraine mechanismsSemantic proximity Read ↗

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Dominant negative effects of a non-conducting TREK1 splice variant expressed in brain.Semantic proximity Read ↗

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A TRPM7 mutation linked to familial trigeminal neuralgia: Omega current and hyperexcitability of trigeminal ganglion neurons.Semantic proximity Read ↗

Functional Expression of TRESK-2, a New Member of the Tandem-pore K+ Channel FamilySemantic proximity Read ↗

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