Article

The novel immunosuppressant Cloxyquin activates hTRESK by allosteric modulation of the selectivity filter

2023-03-07

Abstract excerpt

<title>Abstract</title> <p>The TWIK-related spinal cord K<sup>+</sup> channel (TRESK) is a K<sub>2P</sub> channel contributing to the maintenance of membrane potentials in various cells. Recently, physiological TRESK function was identified as a key player in T-cell differentiation rendering the channel a new pharmacological target for treatment of autoimmune diseases. The channel activator cloxyquin represents a...

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Literature Corpus work: 5ab24217-7833-51fe-a72f-c85fbeaffdc7
DOI: 10.21203/rs.3.rs-2384580/v1

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