Article

Disentangling Schwann Cell and Neuronal TRPA1 Function in Mouse Models of Familial Episodic Pain Syndrome

2026-02-17

Abstract excerpt

<h4>Summary</h4> Familial Episodic Pain Syndrome (FEPS) is a rare inherited disorder characterized by episodes of severe upper-body pain triggered by different stimuli including cold, stress, or fasting. A gain-of-function point mutation (N855S) in the Transient Receptor Potential Ankyrin 1 (TRPA1) ion channel has been identified in affected individuals, altering its biophysical properties, and leading to sustain...

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Literature Corpus work: d35d1fc0-619f-56e4-9f6e-1b150fcf4cf9
DOI: 10.64898/2026.02.14.705765

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