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Article

Properties, regulation, pharmacology, and functions of the K₂p channel, TRESK.

Pflugers Archiv : European journal of physiology - 1 May 2015

Enyedi Péter, Czirják Gábor

Abstract excerpt

TWIK-related spinal cord K(+) channel (TRESK) is the gene product of KCNK18, the last discovered leak potassium K2P channel gene. Under resting conditions, TRESK is constitutively phosphorylated at two regulatory regions. Protein kinase A (PKA) and microtubule affinity-regulating (MARK) kinases can be applied in experiments to phosphorylate these sites of TRESK expressed in Xenopus oocytes, respectively. Upon...

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Source

Identifiers

PMID: 25366493
DOI: 10.1007/s00424-014-1634-8

Genes

KCNK18

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Properties, regulation, pharmacology, and functions of the K₂p channel, TRESK.PMID 25366493Read ↗

KCNK18 c.1107del frameshift in peripheral neuropathy links TRESK dysfunction to neuropathic painSemantic proximity Read ↗

TRESK K <sup>+</sup> Channel Activity Regulates Trigeminal Nociception and HeadacheSemantic proximity Read ↗

TRESK background K(+) channel is inhibited by phosphorylation via two distinct pathways.Semantic proximity Read ↗

A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura.Semantic proximity Read ↗

TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones.Semantic proximity Read ↗

Functional analysis of a migraine-associated TRESK K+ channel mutation.Semantic proximity Read ↗

The Background K+ Channel TRESK in Sensory Physiology and Pain.Semantic proximity Read ↗

Functional Expression of TRESK-2, a New Member of the Tandem-pore K+ Channel FamilySemantic proximity Read ↗

A causal role for TRESK loss of function in migraine mechanismsSemantic proximity Read ↗

The LQLP calcineurin docking site is a major determinant of the calcium-dependent activation of human TRESK background K+ channel.Semantic proximity Read ↗

Critical contribution of the intracellular C-terminal region to TRESK channel activity is revealed by the epithelial Na+ current ratio method.Semantic proximity Read ↗

Zinc and mercuric ions distinguish TRESK from the other two-pore-domain K+ channels.Semantic proximity Read ↗

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