Article
A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura.
Nature medicine - 1 Oct 2010
Lafrenière Ronald G, Cader M Zameel, Poulin Jean-François, Andres-Enguix Isabelle, Simoneau Maryse, Gupta Namrata, Boisvert Karine, Lafrenière François, McLaughlan Shannon, Dubé Marie-Pierre, Marcinkiewicz Martin M, Ramagopalan Sreeram, Ansorge Olaf, Brais Bernard, Sequeiros Jorge, Pereira-Monteiro Jose Maria, Griffiths Lyn R, Tucker Stephen J, Ebers George, Rouleau Guy A
Abstract excerpt
Migraine with aura is a common, debilitating, recurrent headache disorder associated with transient and reversible focal neurological symptoms. A role has been suggested for the two-pore domain (K2P) potassium channel, TWIK-related spinal cord potassium channel (TRESK, encoded by KCNK18), in pain pathways and general anaesthesia. We therefore examined whether TRESK is involved in migraine by screening the KCNK18...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.