Article

Cold Receptor TRPM8 as a target for Migraine-associated Pain and Affective Comorbidities

2025-04-16

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Genetic variations in the Trpm8 gene that encodes the cold receptor TRPM8 have been linked to protection against polygenic migraine, a disabling condition primarily affecting women. Noteworthy, TRPM8 has been recently found in brain areas related to emotional processing, suggesting an unrecognized role in migraine comorbidities. Here, we use mouse behavioural mo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e0d934c8-4549-508a-aea9-b5ec8e68f21e
DOI: 10.21203/rs.3.rs-6305891/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cold Receptor TRPM8 as a target for Migraine-associated Pain and Affective ComorbiditiesDOI 10.21203/rs.3.rs-6305891/v1Read

Cold Receptor TRPM8 as a target for Migraine-associated Pain and Affective ComorbiditiesSemantic proximity Read

Reduced TRPM8 expression underpins reduced migraine risk and attenuated cold pain sensation in humans.Semantic proximity Read

Androgenic TRPM8 activity drives sexual dimorphism in a murine model of chronic migraineSemantic proximity Read

TRPM8.Semantic proximity Read

TRPM8 contributes to sex dimorphism by promoting recovery of normal sensitivity in a mouse model of chronic migraineSemantic proximity Read

TRPA1 gene variants hurting our feelings.Semantic proximity Read

Targeting G <sub>i/o</sub> -coupled GPCRs to inhibit nociceptors: insights from the serotonin receptor Htr1b and triptansSemantic proximity Read

Disentangling Schwann Cell and Neuronal TRPA1 Function in Mouse Models of Familial Episodic Pain SyndromeSemantic proximity Read

Mrgprb4-Lineage Neurons Participate in Intervention of TENS on Chronic Pain and Anxiety-like Symptoms in Inflammatory Pain Mice ModelSemantic proximity Read

Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor.Semantic proximity Read

Translational impact of basic science promotes a new era of precision medicine for migraineSemantic proximity Read

Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine.Semantic proximity Read