Article

KCNK18 c.1107del frameshift in peripheral neuropathy links TRESK dysfunction to neuropathic pain

2025-12-10

Abstract excerpt

Neuropathic pain is commonly accompanied by hyperexcitability of nociceptive neurons, which is driven by regulation of several ion channels, including two-pore domain potassium channels (K2P) that stabilize the resting membrane potential. The TWIK-Related Spinal cord potassium channel (TRESK, K2p18.1) is predominantly expressed in sensory ganglia, where it provides major background K⁺ conductance. We describe a he...

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Literature Corpus work: 4fb9d340-05a9-5c94-81c4-1c79b19d7b80
DOI: 10.64898/2025.12.08.692748

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