Article

TRESK K <sup>+</sup> Channel Activity Regulates Trigeminal Nociception and Headache

2019-06-21

Abstract excerpt

Although dominant-negative mutations of TRESK background K + channel have been reported in migraine patients, whether TRESK activity controls the generation of trigeminal pain, especially headache, is not established. We found that loss of TRESK in all trigeminal ganglia (TG) neurons preferentially increased the intrinsic excitability of small-diameter TG nociceptors that express neuropeptide CGRP or TRPM8 channe...

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Literature Corpus work: ae07668e-c64b-5e7b-bd2e-adbfe27068cb
DOI: 10.1101/679530

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