Differential effects induced by N-hydroxy-2-acetylaminofluorene and N-hydroxy-2-aminofluorene in DNA excision-repair-deficient Chinese hamster cells.

doi:10.1016/0165-7992(88)90109-1

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Article

Differential effects induced by N-hydroxy-2-acetylaminofluorene and N-hydroxy-2-aminofluorene in DNA excision-repair-deficient Chinese hamster cells.

Mutation research - 1 Jan 2000

Okinaka R T, Whaley T W, Strniste G F

Abstract excerpt

The direct-acting cytotoxic properties of N-hydroxy-2-acetylaminofluorene (N-OH-AAF) and N-hydroxy-2-aminofluorene (N-OH-AF) have been determined in repair-proficient (AA8-4) and repair-deficient (UV-5) Chinese hamster ovary cells. Cytotoxicity comparisons indicate that UV-5 cells are considerabl...

Topics

2-Acetylaminofluorene
Animals
Cell Division
Cricetinae
DNA Repair
Fluorenes
Hydroxyacetylaminofluorene
Mutation
Ultraviolet Rays

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