Article
Comparative mutagenesis by aminofluorene derivatives. A possible effect of DNA configuration.
Mutation research - 1 Jan 2000
Heller E P, Rosenkranz E J, McCoy E C, Rosenkranz H S
Abstract excerpt
The mutagenicity of N-acetoxy-N-2-acetylaminofluorene (N-acetoxy- 2AAF ) for Salmonella typhimuricum TA98 is greatly reduced when compared to that of N-hydroxy-2-aminofluorene. This decrease in mutagenic response is accompanied by the formation of a deoxyguanosine-2-acetylaminofluorene adduct. Th...
Topics
- Chromatography, High Pressure Liquid
- DNA, Bacterial
- Fluorenes
- Mutagenicity Tests
- Mutagens
- Mutation
- Nucleic Acid Conformation
- Salmonella typhimurium
- Structure-Activity Relationship