Article
Acetylaminofluorene bound to different guanines of the sequence -GGCGCC- is excised with different efficiencies by the UvrABC excision nuclease in a pattern not correlated to the potency of mutation induction.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1990
Seeberg E, Fuchs R P
Abstract excerpt
DNA fragments were constructed in which acetylaminofluorene adducts were introduced specifically at each one of the three different guanines of the 6-base-pair sequence -GGCGCC-. Incubation of the DNA with the UvrABC excision nuclease in vitro revealed major differences in the efficiency of adduct excision depending on the site of modification. Oligonucleotide excision of adducts bound to the second guanine was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.