Article
Acetylaminofluorene bound to different guanines of the sequence -GGCGCC- is excised with different efficiencies by the UvrABC excision nuclease in a pattern not correlated to the potency of mutation induction.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1990
Seeberg E, Fuchs R P
Abstract excerpt
DNA fragments were constructed in which acetylaminofluorene adducts were introduced specifically at each one of the three different guanines of the 6-base-pair sequence -GGCGCC-. Incubation of the DNA with the UvrABC excision nuclease in vitro revealed major differences in the efficiency of adduc...
Topics
- 2-Acetylaminofluorene
- Base Sequence
- DNA
- Deoxyribonuclease I
- Endodeoxyribonucleases
- Escherichia coli Proteins
- Guanine
- Molecular Sequence Data
- Mutation
- Nucleotide Mapping
- Oligonucleotides