Methoxyamine modification of abasic sites protects CHO cells from the cytotoxic and mutagenic effects of oxygen alkylation.

doi:10.1093/carcin/13.1.87

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Article

Methoxyamine modification of abasic sites protects CHO cells from the cytotoxic and mutagenic effects of oxygen alkylation.

Carcinogenesis - 1 Jan 1992

Fortini P, Rosa S, Zijno A, Calcagnile A, Bignami M, Dogliotti E

Abstract excerpt

The biological effects of the interaction of methoxyamine (MX) with apurinic/apyrimidinic (AP) sites produced in CHO cells by treatment with alkylating agents were examined. A decrease in cytotoxicity was observed after a 10 min treatment with the SN1 alkylating agents ethylnitrosourea (ENU), N-e...

Topics

Alkylating Agents
Animals
Base Sequence
CHO Cells
Cell Survival
Cricetinae
DNA
DNA-(Apurinic or Apyrimidinic Site) Lyase
Deoxyribonuclease IV (Phage T4-Induced)
Endodeoxyribonucleases
Hydroxylamines
Molecular Sequence Data
Mutation
Oligonucleotides
Oxygen
Sister Chromatid Exchange

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PMID: 1370769
DOI: 10.1093/carcin/13.1.87

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1370769-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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