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Methoxyamine modification of abasic sites protects CHO cells from the cytotoxic and mutagenic effects of oxygen alkylation.

Carcinogenesis - 1 Jan 1992

Fortini P, Rosa S, Zijno A, Calcagnile A, Bignami M, Dogliotti E

Abstract excerpt

The biological effects of the interaction of methoxyamine (MX) with apurinic/apyrimidinic (AP) sites produced in CHO cells by treatment with alkylating agents were examined. A decrease in cytotoxicity was observed after a 10 min treatment with the SN1 alkylating agents ethylnitrosourea (ENU), N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) and N-methyl-nitrosourea when MX was present in the culture medium. Furthermore...

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PMID: 1370769
DOI: 10.1093/carcin/13.1.87

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