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Article

Involvement of different pathways in the genotoxicity of nitropropanes in cultured mammalian cells.

Mutagenesis - 1 Jul 1990

Roscher E, Ziegler-Skylakakis K, Andrae U

Abstract excerpt

The metabolic pathways leading to genotoxicity of nitropropanes in mammalian cells were investigated by measuring the effects of 2-nitropropane (2-NP) and 1-nitropropane (1-NP) on various cell lines characterized for their expression of cytochrome P450-dependent mono-oxygenases. Cells used were the rat hepatoma cell lines 2sFou, H4IIEC3/G- and C2Rev7, which express various forms of cytochrome P450-dependent...

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PMID: 2398819
DOI: 10.1093/mutage/5.4.375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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