Involvement of different pathways in the genotoxicity of nitropropanes in cultured mammalian cells.

doi:10.1093/mutage/5.4.375

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Article

Involvement of different pathways in the genotoxicity of nitropropanes in cultured mammalian cells.

Mutagenesis - 1 Jul 1990

Roscher E, Ziegler-Skylakakis K, Andrae U

Abstract excerpt

The metabolic pathways leading to genotoxicity of nitropropanes in mammalian cells were investigated by measuring the effects of 2-nitropropane (2-NP) and 1-nitropropane (1-NP) on various cell lines characterized for their expression of cytochrome P450-dependent mono-oxygenases. Cells used were the rat hepatoma cell lines 2sFou, H4IIEC3/G- and C2Rev7, which express various forms of cytochrome P450-dependent...

Topics

Alkanes
Animals
Biotransformation
Cell Line
Cell Survival
Cricetinae
Cytochrome P-450 Enzyme System
DNA Repair
Drug Resistance
Liver Neoplasms, Experimental
Micronucleus Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mixed Function Oxygenases

Mutation

Nitroparaffins

Oxygenases

Propane

Rats

Thioguanine

Source

Open in PubMed

Identifiers

PMID: 2398819
DOI: 10.1093/mutage/5.4.375

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2398819-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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