Differential effect of acetyltransferase expression on the genotoxicity of heterocyclic amines in CHO cells.

doi:10.1016/s0165-1218(97)00005-0

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Article

Differential effect of acetyltransferase expression on the genotoxicity of heterocyclic amines in CHO cells.

Mutation research - 24 Apr 1997

Wu R W, Tucker J D, Sorensen K J, Thompson L H, Felton J S

Abstract excerpt

We earlier developed the Chinese hamster ovary UV5P3 cell line that expresses cytochrome P4501A2 and lacks nucleotide excision repair for studying metabolism and mutagenicity of heterocyclic amines. The Chinese hamster ovary UV5P3 cells are approximately 50-fold more sensitive to the cooked food...

Topics

Acetyltransferases
Animals
Arylamine N-Acetyltransferase
CHO Cells
Cell Survival
Cricetinae
Humans
Imidazoles
Mutagenesis
Mutagenicity Tests
Mutagens
Mutation
Quinolines
Recombinant Proteins
Salmonella
Transfection

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