Polymorphism in N-2-acetylaminofluorene induced DNA structure as revealed by DNase I footprinting.

doi:10.1093/nar/19.20.5603

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Article

Polymorphism in N-2-acetylaminofluorene induced DNA structure as revealed by DNase I footprinting.

Nucleic acids research - 25 Oct 1991

Veaute X, Fuchs R P

Abstract excerpt

In this paper, we have constructed double stranded helices (60-mers) containing a single N-2-acetylaminofluorene (-AAF) adduct covalently bound to one of the three guanine residues of the Narl site (G1G2CG3CC). This sequence was identified as a strong frameshift mutation hot spot for many carcino...

Topics

2-Acetylaminofluorene
Base Sequence
DNA
DNA Damage
Deoxyribonuclease I
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Polymorphism, Genetic

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