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Article

Polymorphism in N-2-acetylaminofluorene induced DNA structure as revealed by DNase I footprinting.

Nucleic acids research - 25 Oct 1991

Veaute X, Fuchs R P

Abstract excerpt

In this paper, we have constructed double stranded helices (60-mers) containing a single N-2-acetylaminofluorene (-AAF) adduct covalently bound to one of the three guanine residues of the Narl site (G1G2CG3CC). This sequence was identified as a strong frameshift mutation hot spot for many carcinogens that bind to the C8 position of guanine. Using DNase I as a probe for DNA conformation we show i) that the average...

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Identifiers

PMID: 1945836
DOI: 10.1093/nar/19.20.5603
PMCID: PMC328963

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Polymorphism in N-2-acetylaminofluorene induced DNA structure as revealed by DNase I footprinting.PMID 1945836Read ↗

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