Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotoxicity of 2,6- and 3,5-dimethylaniline in cultured mammalian cells: the role of reactive oxygen species.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Nov 2012

Chao Ming-Wei, Kim Min Young, Ye Wenjie, Ge Jing, Trudel Laura J, Belanger Crystal L, Skipper Paul L, Engelward Bevin P, Tannenbaum Steven R, Wogan Gerald N

Abstract excerpt

Several alkylanilines with structures more complex than toluidines have been associated epidemiologically with human cancer. Their mechanism of action remains largely undetermined, and there is no reported evidence that it replicates that of multicyclic aromatic amines even though the principal metabolic pathways of P450-mediated hydroxylation and phase II conjugation are very similar. As a means to elucidate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aniline Compounds
Share to CHO Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cricetulus

Share to DNA Adducts

Share to DNA Breaks, Double-Stranded

Share to Microsomes, Liver

Share to Mutagenicity Tests

Share to Mutagens

Source

Open in PubMed Open full text

Identifiers

PMID: 22831970
DOI: 10.1093/toxsci/kfs229
PMCID: PMC3621364

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotoxicity of 2,6- and 3,5-dimethylaniline in cultured mammalian cells: the role of reactive oxygen species.PMID 22831970Read ↗

Comparative evaluation of three methylene dianiline isomers in the bacterial reverse mutation assay, the in vitro gene mutation test, and the in vitro chromosomal aberration test.Semantic proximity Read ↗

Acute exposure to DEHP metabolite, MEHP cause genotoxicity, mutagenesis and carcinogenicity in mammalian Chinese hamster ovary cells.Semantic proximity Read ↗

Genotoxicity induced in human lymphoblasts by atmospheric reaction products of naphthalene and phenanthrene.Semantic proximity Read ↗

Effect of N-acetyltransferase 2 genetic polymorphism on 4,4'-methylenebis(2-chloroaniline)-induced genotoxicity and oxidative stress.Semantic proximity Read ↗

Mechanisms of formation, genotoxicity, and mutation of guanine oxidation products.Semantic proximity Read ↗

Follow-up genotoxicity assessment of Ames-positive/equivocal chemicals using the improved thymidine kinase gene mutation assay in DNA repair-deficient human TK6 cells.Semantic proximity Read ↗

Analysis of the genotoxicity of anthraquinone dyes in the mouse lymphoma assay.Semantic proximity Read ↗

Acrylamide-induced molecular mutation spectra at HPRT locus in human promyelocytic leukaemia HL-60 and NB4 cell lines.Semantic proximity Read ↗

Development of an integrated assay in human TK6 cells to permit comprehensive genotoxicity analysis in vitro.Semantic proximity Read ↗

Cytotoxicity and genotoxicity of the carcinogen aristolochic acid I (AA-I) in human bladder RT4 cells.Semantic proximity Read ↗

Thiopurines, DNA damage, DNA repair and therapy-related cancerSemantic proximity Read ↗

Aromatic amines and cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.