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Article

Folding perspectives of an intrinsically disordered transactivation domain and its single mutation breaking the folding propensity.

International journal of biological macromolecules - 15 Jul 2020

Sharma Nitin, Fonin Alexander V, Shpironok Olesya G, Silonov Sergey A, Turoverov Konstantin K, Uversky Vladimir N, Kuznetsova Irina M, Giri Rajanish

Abstract excerpt

Transcriptional regulation is a critical facet of cellular development controlled by numerous transcription factors, among which are E-proteins (E2A, HEB, and E2-2) that play important roles in lymphopoiesis. For example, primary hematopoietic cells immortalisation is promoted by interaction of the conserved PCET motif consisting of the Leu-X-X-Leu-Leu (LXXLL) and Leu-Asp-Phe-Ser (LDFS) sequences of the...

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Identifiers

PMID: 31733244
DOI: 10.1016/j.ijbiomac.2019.11.111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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