Article

The Participation of the Intrinsically Disordered Regions of the bHLH-PAS Transcription Factors in Disease Development

2020-10-26

Abstract excerpt

The bHLH-PAS proteins are a family of transcription factors regulating expression of a wide range of genes involved in different functions, from differentiation and development control, by oxygen and toxins sensing to circadian clock setting. In addition to the well-preserved DNA-binding bHLH and PAS domains, bHLH-PAS proteins contain long intrinsically disordered C-terminal regions, responsible for their activity...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 62f9ed55-18f7-5c29-ae26-f00b5c81bffb
DOI: 10.20944/preprints202010.0510.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Participation of the Intrinsically Disordered Regions of the bHLH-PAS Transcription Factors in Disease DevelopmentDOI 10.20944/preprints202010.0510.v1Read

The Participation of the Intrinsically Disordered Regions of the bHLH-PAS Transcription Factors in Disease Development.Semantic proximity Read

Phase Separation as a Missing Mechanism for Interpretation of Disease Mutations.Semantic proximity Read

An activity-specificity trade-off encoded in human transcription factors.Semantic proximity Read

The PRALINE database: Protein and Rna humAn singLe nucleotIde variaNts in condEnsatesSemantic proximity Read

Missense mutations in intrinsically disordered protein regions link pathogenicity and phase separationSemantic proximity Read

Disordered but Different: Functional and Evolutionary Divergence of Transcription Factor Intrinsically Disordered RegionsSemantic proximity Read

Ancient evolutionary origin of intrinsically disordered cancer risk regionsSemantic proximity Read

Is there a role of phase partitioning in coordinating DNA damage response?Semantic proximity Read

Disease mutations in disordered regions--exception to the rule?Semantic proximity Read

Condensate formation of the human RNA-binding protein SMAUG1 is controlled by its intrinsically disordered regions and interactions with 14-3-3 proteinsSemantic proximity Read

DisPhaseDB, an integrative database of diseases related variations in liquid-liquid phase separation proteinsSemantic proximity Read

Phase separation as a possible mechanism for dosage sensitivity.Semantic proximity Read