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Article

Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex degron and Keap1.

Molecular and cellular biology - 1 Mar 2014

Fukutomi Toshiaki, Takagi Kenji, Mizushima Tsunehiro, Ohuchi Noriaki, Yamamoto Masayuki

Abstract excerpt

Transcription factor Nrf2 (NF-E2-related factor 2) coordinately regulates cytoprotective gene expression, but under unstressed conditions, Nrf2 is degraded rapidly through Keap1 (Kelch-like ECH-associated protein 1)-mediated ubiquitination. Nrf2 harbors two Keap1-binding motifs, DLG and ETGE. Interactions between these two motifs and Keap1 constitute a key regulatory nexus for cellular Nrf2 activity through the...

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Identifiers

PMID: 24366543
DOI: 10.1128/MCB.01191-13
PMCID: PMC4023822

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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