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Targeting mechanism of the retinoblastoma tumor suppressor by a prototypical viral oncoprotein

20 Jan 2010

Abstract excerpt

DNA tumor viruses ensure genome amplification by hijacking the cellular replication machinery and forcing infected cells to enter the S phase. The retinoblastoma (Rb) protein controls the G1/S checkpoint, and is targeted by several viral oncoproteins, among these the E7 protein from human papillomaviruses (HPVs). A quantitative investigation of the interaction mechanism between the HPV16 E7 protein and the RbAB...

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PMID: 20088881
DOI: 10.1111/j.1742-4658.2009.07540.x

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