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Article

Structural basis of CBP/p300 recruitment in leukemia induction by E2A-PBX1.

Blood - 8 Nov 2012

Denis Christopher M, Chitayat Seth, Plevin Michael J, Wang Feng, Thompson Patrick, Liu Shuang, Spencer Holly L, Ikura Mitsuhiko, LeBrun David P, Smith Steven P

Abstract excerpt

E-proteins are critical transcription factors in B-cell lymphopoiesis. E2A, 1 of 3 E-protein-encoding genes, is implicated in the induction of acute lymphoblastic leukemia through its involvement in the chromosomal translocation 1;19 and consequent expression of the E2A-PBX1 oncoprotein. An interaction involving a region within the N-terminal transcriptional activation domain of E2A-PBX1, termed the PCET motif,...

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Source

Identifiers

PMID: 22972988
DOI: 10.1182/blood-2012-02-411397

Genes

PBX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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