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Article

Structure of Radical-Induced Cell Death1 Hub Domain Reveals a Common αα-Scaffold for Disorder in Transcriptional Networks.

Structure (London, England : 1993) - 1 May 2018

Bugge Katrine, Staby Lasse, Kemplen Katherine R, O'Shea Charlotte, Bendsen Sidsel K, Jensen Mikael K, Olsen Johan G, Skriver Karen, Kragelund Birthe B

Abstract excerpt

Communication within cells relies on a few protein nodes called hubs, which organize vast interactomes with many partners. Frequently, hub proteins are intrinsically disordered conferring multi-specificity and dynamic communication. Conversely, folded hub proteins may organize networks using disordered partners. In this work, the structure of the RST domain, a unique folded hub, is solved by nuclear magnetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29657132
DOI: 10.1016/j.str.2018.03.013

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PAH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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