Do intrinsically disordered proteins possess high specificity in protein-protein interactions?

Abstract excerpt

Specific protein-protein interactions are critical to cellular function. Structural flexibility and disorder-to-order transitions upon binding enable intrinsically disordered proteins (IDPs) to overcome steric restrictions and form complementary binding interfaces, and thus, IDPs are widely considered to have high specificity and low affinity for molecular recognition. However, flexibility may also enable IDPs to...

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