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Article

Acute myeloid leukaemia genomics.

British journal of haematology - 1 Nov 2017

Medinger Michael, Passweg Jakob R

Abstract excerpt

Acute myeloid leukaemia (AML) is a biologically complex, molecularly and clinically heterogeneous disease. Despite major advances in understanding the genetic landscape of AML and its impact on the pathophysiology and biology of the disease, standard treatment options have not significantly changed during the past three decades. AML is characterized by multiple somatically acquired mutations that affect genes of...

Topics

Carcinogenesis
Epigenesis, Genetic
Genes, ras
Genomics
Humans
Leukemia, Myeloid, Acute
Molecular Targeted Therapy
Mutation
Mutation Accumulation
Nuclear Proteins
Nucleophosmin
Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

fms-Like Tyrosine Kinase 3

Source

Identifiers

PMID: 28653397
DOI: 10.1111/bjh.14823

Genes

ASXL1
FLT3
IDH1
IDH2
NPM1
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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