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Article

Clonal dynamics in a case of acute monoblastic leukemia that later developed myeloproliferative neoplasm.

International journal of hematology - 1 Aug 2018

Sato Shinya, Itonaga Hidehiro, Taguchi Masataka, Sawayama Yasushi, Imanishi Daisuke, Tsushima Hideki, Hata Tomoko, Moriuchi Yukiyoshi, Mishima Hiroyuki, Kinoshita Akira, Yoshiura Koh-Ichiro, Miyazaki Yasushi

Abstract excerpt

In acute myeloid leukemia (AML), patients may harbor pre-leukemic hematopoietic stem cells (HSCs) containing some, but not all, of the mutations observed in the leukemic cells. These pre-leukemic HSCs may survive induction chemotherapy and contribute to AML relapse by obtaining additional mutations. We report here an acute monoblastic leukemia (AMoL) patient who later developed an unclassifiable...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Induction Chemotherapy

Share to Leukemia, Monocytic, Acute

Share to Myeloproliferative Disorders

Share to Neoplasm Recurrence, Local

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Source

Identifiers

PMID: 29417354
DOI: 10.1007/s12185-018-2419-1

Genes

GATA2
SRSF2
TET2
ASXL1
CBL
JAK2
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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