Article
Genetic and Genomic Landscape of Secondary and Therapy-Related Acute Myeloid Leukemia.
Genes - 6 Jul 2020
Higgins Alexandra, Shah Mithun Vinod
Abstract excerpt
A subset of acute myeloid leukemia (AML) arises either from an antecedent myeloid malignancy (secondary AML, sAML) or as a complication of DNA-damaging therapy for other cancers (therapy-related myeloid neoplasm, t-MN). These secondary leukemias have unique biological and clinical features that distinguish them from de novo AML. Over the last decade, molecular techniques have unraveled the complex subclonal...
Topics
- Clonal Hematopoiesis
- Humans
- Leukemia, Myeloid, Acute
- Mutation
- Myelodysplastic Syndromes
- Myeloproliferative Disorders
- Neoplasms, Second Primary