Article
Acute myeloid leukemia ontogeny is defined by distinct somatic mutations.
Blood - 26 Feb 2015
Lindsley R Coleman, Mar Brenton G, Mazzola Emanuele, Grauman Peter V, Shareef Sarah, Allen Steven L, Pigneux Arnaud, Wetzler Meir, Stuart Robert K, Erba Harry P, Damon Lloyd E, Powell Bayard L, Lindeman Neal, Steensma David P, Wadleigh Martha, DeAngelo Daniel J, Neuberg Donna, Stone Richard M, Ebert Benjamin L
Abstract excerpt
Acute myeloid leukemia (AML) can develop after an antecedent myeloid malignancy (secondary AML [s-AML]), after leukemogenic therapy (therapy-related AML [t-AML]), or without an identifiable prodrome or known exposure (de novo AML). The genetic basis of these distinct pathways of AML development has not been determined. We performed targeted mutational analysis of 194 patients with rigorously defined s-AML or...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.