Article
Genomic mutation patterns and prognostic value in de novo and secondary acute myeloid leukemia: A multicenter study from China.
International journal of cancer - 15 Dec 2024
Dou Xi, Dan Chunli, Zhang Duanzhong, Zhou Hongjing, He Renke, Zhou Guangyu, Zhu Yu, Fu Nan, Niu Ben, Xu Shuangnian, Liao Yi, Luo Zhangqin, Yang Lihua, Zhang Haiguo, Xu Yizhi, Zhan Qian, Chen Wei, Yang Zesong, Tang Xiaoqiong, Zhang Hongbin, Xiao Qing, Chen Jianbin, Liu Lin, Wang Yi, Pei Li, Wang Li
Abstract excerpt
Acute myeloid leukemia (AML) can manifest as de novo AML (dn-AML) or secondary AML (s-AML), with s-AML being associated with inferior survival and distinct genomic characteristics. The underlying reasons for this disparity remain to be elucidated. In this multicenter study, next-generation sequencing (NGS) was employed to investigate the mutational landscape of AML in 721 patients from June 2020 to May...
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