Article
Oxidation of methionine residues activates the high-threshold heat-sensitive ion channel TRPV2.
Proceedings of the National Academy of Sciences of the United States of America - 26 Nov 2019
Fricke Tabea C, Echtermeyer Frank, Zielke Johannes, de la Roche Jeanne, Filipovic Milos R, Claverol Stéphane, Herzog Christine, Tominaga Makoto, Pumroy Ruth A, Moiseenkova-Bell Vera Y, Zygmunt Peter M, Leffler Andreas, Eberhardt Mirjam J
Abstract excerpt
Thermosensitive transient receptor potential (TRP) ion channels detect changes in ambient temperature to regulate body temperature and temperature-dependent cellular activity. Rodent orthologs of TRP vanilloid 2 (TRPV2) are activated by nonphysiological heat exceeding 50 °C, and human TRPV2 is heat-insensitive. TRPV2 is required for phagocytic activity of macrophages which are rarely exposed to excessive heat,...
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