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Article

Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain.

Nature neuroscience - 1 Jun 2010

Grandl Jörg, Kim Sung Eun, Uzzell Valerie, Bursulaya Badry, Petrus Matt, Bandell Michael, Patapoutian Ardem

Abstract excerpt

TRPV1 is the founding and best-studied member of the family of temperature-activated transient receptor potential ion channels (thermoTRPs). Voltage, chemicals and heat allosterically gate TRPV1. Molecular determinants of TRPV1 activation by capsaicin, allicin, acid, ammonia and voltage have been identified. However, the structures and mechanisms mediating TRPV1's pronounced temperature sensitivity remain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20414199
DOI: 10.1038/nn.2552
PMCID: PMC2876202

Genes

TRPV1
TRPV3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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