Article

Missense variant analysis in the TRPV1 ARD reveals the unexpected functional significance of a methionine

2025-02-17

Abstract excerpt

The Transient Receptor Potential Vanilloid sub-type 1 (TRPV1) is an ion channel that is activated by heat, extracellular protons, oxidation, and it is implicated in various aspects of inflammatory pain. In this study, we uncover that residue M308 in the TRPV1 ankyrin repeat domain (ARD) stands out from most other buried ARD residues because of the greater number of human missense variants at this position while ma...

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Literature Corpus work: aaa99aaf-0a06-503c-84b1-1aafab577693
DOI: 10.1101/2025.02.14.638348

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Missense variant analysis in the TRPV1 ARD reveals the unexpected functional significance of a methionineDOI 10.1101/2025.02.14.638348Read

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