Article
Structural origins of species-specific differences in TRPV2 activation.
Nature communications - 20 Aug 2026
Fricke Tabea C, Pumroy Ruth A, Rocereta Julia A, De Jesús-Pérez José J, Oprita George, Meyer Marvin J A, Herzog Christine, Echtermeyer Frank G, Hill Kerstin, Leffler Andreas, Moiseenkova-Bell Vera Y
Abstract excerpt
Transient receptor potential vanilloid 2 (TRPV2) is a broadly expressed ion channel implicated in diverse physiological and pathological processes. Despite strong conservation, human TRPV2 (hTRPV2) displays markedly reduced sensitivity to stimuli such as 2-aminoethoxydiphenyl borate (2-APB) and heat compared to rodent orthologs. Here we combine electrophysiology and cryo electron microscopy to define the basis of...
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