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Article

A differential role of macrophage TRPM2 channels in Ca²⁺ signaling and cell death in early responses to H₂O₂.

American journal of physiology. Cell physiology - 1 Jul 2013

Zou Jie, Ainscough Justin F, Yang Wei, Sedo Alicia, Yu Shu-Ping, Mei Zhu-Zhong, Sivaprasadarao Asipu, Beech David J, Jiang Lin-Hua

Abstract excerpt

Reactive oxygen species such as H₂O₂ elevates the cytosolic Ca²⁺ concentration ([Ca²⁺]c) and causes cell death via poly(ADPR) polymerase (PARP) activation, which also represents the primary mechanism by which H₂O₂ activate the transient receptor potential melastatin-related 2 (TRPM2) channel as a...

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Source

Identifiers

PMID: 23596170
DOI: 10.1152/ajpcell.00390.2012

Genes

TRPM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23596170-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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