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Article

TRPV1 temperature activation is specifically sensitive to strong decreases in amino acid hydrophobicity.

Scientific reports - 3 Apr 2017

Sosa-Pagán Jason O, Iversen Edwin S, Grandl Jörg

Abstract excerpt

Several transient receptor potential (TRP) ion channels can be directly activated by hot or cold temperature with high sensitivity. However, the structures and molecular mechanism giving rise to their high temperature sensitivity are not fully understood. One hypothesized mechanism assumes that temperature activation is driven by the exposure of hydrophobic residues to solvent. This mechanism further predicts...

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Share to Amino Acids
Share to High-Throughput Nucleotide Sequencing
Share to Hydrophobic and Hydrophilic Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ion Channel Gating

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Share to Structure-Activity Relationship

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Source

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Identifiers

PMID: 28373693
DOI: 10.1038/s41598-017-00636-4
PMCID: PMC5428820

Genes

TRPV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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