Article

Modulating Protein Function through Genetically Encoded Oxidative Chemistry

2025-11-06

Abstract excerpt

Oxidative chemistry underlies many endogenous signaling pathways but remains underutilized as a programmable strategy for regulating protein function in living cells. Here we establish genetically encoded oxidative chemistry as a tunable framework for modulating diverse proteins by coupling a photosensitizer to defined intracellular contexts. Using miniSOG to generate reactive oxygen species (ROS), we show that co...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9c84a183-4b4e-5bc3-8aaf-cb952466c04b
DOI: 10.1101/2025.11.06.686050

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modulating Protein Function through Genetically Encoded Oxidative ChemistryDOI 10.1101/2025.11.06.686050Read

Ultra-fast genetically encoded sensor for precise real-time monitoring of physiological and pathophysiological peroxide dynamicsSemantic proximity Read

Structure-guided engineering of a fast genetically encoded sensor for real-time H <sub>2</sub> O <sub>2</sub> monitoringSemantic proximity Read

Oxygen-confined photooxidation represents a novel form of oxidative protein damageSemantic proximity Read

All-optical spatiotemporal mapping of ROS dynamics across mitochondrial microdomains <i>in situ</i>Semantic proximity Read

Sodium channels as gateable non-photonic sensors for membrane-delimited reactive species.Semantic proximity Read

Hidden route of protein damage through confined oxygen gasSemantic proximity Read

Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators.Semantic proximity Read

Optogenetic Regulation of Mitochondrial Function to Modulate Cell DeathSemantic proximity Read

Advances in the Genetically Engineered KillerRed for Photodynamic Therapy ApplicationsSemantic proximity Read

A High-Performance Genetically Encoded Fluorescent Biosensor for Imaging Physiological PeroxynitriteSemantic proximity Read

Creating Red Light-Controlled Protein Dimerization Systems as Genetically Encoded Actuators with High SpecificitySemantic proximity Read

Real-time monitoring of peroxiredoxin oligomerization dynamics in living cells.Semantic proximity Read