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Article

Heat-hypersensitive mutants of ryanodine receptor type 1 revealed by microscopic heating.

Proceedings of the National Academy of Sciences of the United States of America - 9 Aug 2022

Oyama Kotaro, Zeeb Vadim, Yamazawa Toshiko, Kurebayashi Nagomi, Kobirumaki-Shimozawa Fuyu, Murayama Takashi, Oyamada Hideto, Noguchi Satoru, Inoue Takayoshi, Inoue Yukiko U, Nishino Ichizo, Harada Yoshie, Fukuda Norio, Ishiwata Shin'ichi, Suzuki Madoka

Abstract excerpt

Thermoregulation is an important aspect of human homeostasis, and high temperatures pose serious stresses for the body. Malignant hyperthermia (MH) is a life-threatening disorder in which body temperature can rise to a lethal level. Here we employ an optically controlled local heat-pulse method to manipulate the temperature in cells with a precision of less than 1 °C and find that the mutants of ryanodine...

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Identifiers

PMID: 35925888
DOI: 10.1073/pnas.2201286119
PMCID: PMC9371657

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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