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Article

C-terminal dimerization activates the nociceptive transduction channel transient receptor potential vanilloid 1.

The Journal of biological chemistry - 25 Nov 2011

Wang Shu, Chuang Huai-hu

Abstract excerpt

Covalent modification of the specific cysteine residue(s) by oxidative stress robustly potentiates transient receptor potential vanilloid 1 (TRPV1) and sensitizes nociception. Here we provide biochemical evidence of dimerization of TRPV1 subunits upon exposure to phenylarsine oxide and hydrogen peroxide (H(2)O(2)), two chemical surrogates of oxidative stress. A disulfide bond formed between apposing cysteines...

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Source

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Identifiers

PMID: 21926175
DOI: 10.1074/jbc.M111.256669
PMCID: PMC3220497

Genes

TRPV1
TRPV3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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