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Article

Association of 11β-hydroxysteroid dehydrogenase type1 (HSD11b1) gene polymorphisms with outcome of antidepressant therapy and suicide attempts.

Behavioural brain research - 2 Mar 2020

Figaro-Drumond Fernanda Viana, Pereira Sherliane Carla, Menezes Itiana Castro, von Werne Baes Cristiane, Coeli-Lacchini Fernanda Borchers, Oliveira-Paula Gustavo Henrique, Cleare Anthony J, Young Allan H, Tanus-Santos Jose Eduardo, Juruena Mario F, Lacchini Riccardo

Abstract excerpt

The hypothalamic-pituitary-adrenal axis has been implicated in the pathophysiology of depressive disorders. HSD11B1 encodes 11β-hydroxysteroid dehydrogenase type1 enzyme, responsible for converting cortisone to cortisol. Genetic polymorphisms in HSD11B1 may impact in depression outcome and risk of suicide. This study aimed to assess whether HSD11B1 genotypes and haplotypes are associated with depression risk,...

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Identifiers

PMID: 31704233
DOI: 10.1016/j.bbr.2019.112343

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