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Article

11β-Hydroxylase (CYP11B1) gene variants and new-onset depression in later life.

Journal of psychiatry & neuroscience : JPN - 4 Jan 2021

Ancelin Marie-Laure, Norton Joanna, Ritchie Karen, Chaudieu Isabelle, Ryan Joanne

Abstract excerpt

Background: Cumulative exposure to high glucocorticoid levels is detrimental for the brain and may have particular implications in later life. A feature of late-life depression is increased cortisol secretion. Variants in the CYP11B1 gene, which codes for the enzyme responsible for cortisol synthesis, could influence risk of late-life depression, but this hypothesis has not been examined. We investigated the...

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Identifiers

PMID: 33245660
DOI: 10.1503/jpn.190177
PMCID: PMC7955840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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