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Article

Early life stress unravels epistatic genetic associations of cortisol pathway genes with depression.

Journal of psychiatric research - 1 Jul 2024

Pereira Sherliane Carla, Coeli-Lacchini Fernanda Borchers, Pereira Daniela Alves, Ferezin Letícia Perticarrara, Menezes Itiana Castro, Baes Cristiane von Werne, Luizon Marcelo Rizzatti, Juruena Mario F, Cleare Anthony J, Young Allan H, Lacchini Riccardo

Abstract excerpt

Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis represents one of the most consistent pathophysiological findings in depressive disorders. Cortisol signaling is affected by proteins that mediate its cellular responses or alters its availability to mineralocorticoid and glucocorticoid receptors. In our study, we evaluated candidate genes that may influence the risk for depression and suicide due to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38759498
DOI: 10.1016/j.jpsychires.2024.05.032

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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