Article
The effect of common genetic variation in 11β-hydroxysteroid dehydrogenase type 1 on hypothalamic-pituitary-adrenal axis activity and incident depression.
The Journal of clinical endocrinology and metabolism - 1 Feb 2012
Dekker M J H J, Tiemeier H, Luijendijk H J, Kuningas M, Hofman A, de Jong F H, Stewart P M, Koper J W, Lamberts S W J
Abstract excerpt
BACKGROUND: Accumulating evidence suggests that hyperactivity of the hypothalamic-pituitary-adrenal axis (HPA axis) is involved in depression. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts inert cortisone to active cortisol and is implicated in HPA axis regulation in animal studies. The aim of our study was to identify polymorphisms in 11β-HSD1 gene (HSD11B1) with consistent associations with...
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