Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The impact of HTR1A and HTR1B methylation combined with stress/genotype on early antidepressant efficacy.

Psychiatry and clinical neurosciences - 1 Feb 2022

Xu Zhi, Chen Zimu, Shen Tian, Chen Lei, Tan Tingting, Gao Chenjie, Chen Bingwei, Yuan Yonggui, Zhang Zhijun

Abstract excerpt

AIMS: Antidepressants are effective in the treatment of major depressive disorder (MDD), while many patients fail to respond to antidepressants. Both 5-HT1A (HTR1A) and 5-HT1B (HTR1B) receptors play an important role in antidepressant activity. Meanwhile, DNA methylation is associated with MDD and antidepressant efficacy. In this study we investigate the influence of HTR1A and HTR1B methylation combined with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antidepressive Agents
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Depressive Disorder, Major

Share to DNA Methylation

Share to Receptor, Serotonin, 5-HT1A

Share to Receptor, Serotonin, 5-HT1B

Share to Stress, Psychological

Share to Treatment Outcome

Source

Identifiers

PMID: 34773671
DOI: 10.1111/pcn.13314

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The impact of HTR1A and HTR1B methylation combined with stress/genotype on early antidepressant efficacy.PMID 34773671Read ↗

HTR1A/1B DNA methylation may predict escitalopram treatment response in depressed Chinese Han patients.Semantic proximity Read ↗

Influence and interaction of genetic polymorphisms in the serotonin system and life stress on antidepressant drug response.Semantic proximity Read ↗

TPH-2 Polymorphisms Interact with Early Life Stress to Influence Response to Treatment with Antidepressant Drugs.Semantic proximity Read ↗

Early life stress unravels epistatic genetic associations of cortisol pathway genes with depression.Semantic proximity Read ↗

Association of DNA methylation in BDNF with escitalopram treatment response in depressed Chinese Han patients.Semantic proximity Read ↗

Influence of genetic polymorphisms involved in the hypothalamic-pituitary-adrenal axis and their interactions with environmental factors on antidepressant response.Semantic proximity Read ↗

Association between HTR1B alleles and suicidal ideation in individuals with major depressive disorder.Semantic proximity Read ↗

Association of Serotonin Transporter Gene AluJb Methylation with Major Depression, Amygdala Responsiveness, 5-HTTLPR/rs25531 Polymorphism, and Stress.Semantic proximity Read ↗

Stress exposure and psychopathology alter methylation of the serotonin receptor 2A (HTR2A) gene in preschoolers.Semantic proximity Read ↗

Strong effects of environmental factors on prevalence and course of major depressive disorder are not moderated by 5-HTTLPR polymorphisms in a large Dutch sample.Semantic proximity Read ↗

Association of the C(-1019)G 5-HT1A promoter polymorphism with exposure to stressors preceding hospitalization for bipolar depression.Semantic proximity Read ↗

Influence of the interaction between the serotonin 1A receptor C-1019G polymorphism and negative life stressors on the development of depression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.