HTR1A/1B DNA methylation may predict escitalopram treatment response in depressed Chinese Han patients.

doi:10.1016/j.jad.2017.12.010

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Article

HTR1A/1B DNA methylation may predict escitalopram treatment response in depressed Chinese Han patients.

Journal of affective disorders - 1 Mar 2018

Wang Peipei, Lv Qinyu, Mao Yemeng, Zhang Cuizhen, Bao Chenxi, Sun Hong, Chen Hanmei, Yi Zhenghui, Cai Weimin, Fang Yiru

Abstract excerpt

BACKGROUND: The serotonin receptor 1A and 1B (HTR1A/1B) gene have been suggested to be involved in the pathogenesis of major depressive disorder (MDD) and the antidepressant treatment response. Gene expression differences were partly mediated by genetic polymorphism and DNA methylation which migh...

Topics

Adult
Antidepressive Agents, Second-Generation
Asian People
Citalopram
DNA Methylation
Depression
Depressive Disorder, Major
Female
Genotype
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Psychiatric Status Rating Scales
Receptor, Serotonin, 5-HT1A

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Open in PubMed

Identifiers

PMID: 29275155
DOI: 10.1016/j.jad.2017.12.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-29275155-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Receptor, Serotonin, 5-HT1B

Stress, Psychological