Article

Conserved T cell receptor usage underpins recognition of CD1c presenting a mycobacterial lipid

2026-06-22

Abstract excerpt

The mechanism by which T cell receptors (TCR) recognise mycobacterial lipids presented by CD1 family members not well understood. We used CD1c tetramers loaded with the mycobacterial phosphomycoketide (PM) or mannosyl-PM (MPM) to isolate T cells ex vivo in healthy blood donors and in individuals from a tuberculosis (TB)-endemic region of South Africa, with higher frequencies observed in individuals from the TB-en...

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Identifiers and source

Literature Corpus work: 92c80c1a-2245-50b9-8ec7-69a633910a1e
DOI: 10.64898/2026.06.17.733038

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