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Article

Sequence and Structural Analyses Reveal Distinct and Highly Diverse Human CD8+ TCR Repertoires to Immunodominant Viral Antigens

1 Apr 2017

Abstract excerpt

A diverse T cell receptor (TCR) repertoire is essential for controlling viral infections. However, information about TCR repertoires to defined viral antigens is limited. We performed a comprehensive analysis of CD8 + TCR repertoires for two dominant viral epitopes: pp65 495–503 (NLV) of cytomegalovirus and M1 58–66 (GIL) of influenza A virus. The highly individualized repertoires (87–5,533 α or β clonotypes per...

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Identifiers

PMID: 28423320
DOI: 10.1016/j.celrep.2017.03.072

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